Focal skin toxicity related to methotrexate sparing psoriatic plaques.
Dermatol Online J
; 16(6): 16, 2010 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-20579471
ABSTRACT
Methotrexate (MTX) is an antimetabolite and antifolate drug used in the treatment of cancer and autoimmune diseases. MTX inhibits DNA synthesis by competitive inhibition of dihydrofolate reductase in immunologically active cells. It also decreases inflammation by other mechanisms. Cutaneous toxicity is usually dose-related and generally occurs when recommended guidelines are ignored or there is a decrease in renal excretion. Self-medication is a problem with unknown prevalence. Signs of MTX toxicity include bone marrow suppression, hepatotoxicity, and mucocutaneous toxicity. Painful erosions of psoriatic plaques and, less commonly, erosions in patients without psoriasis have been reported as an early sign of MTX toxicity. To our knowledge, this is the first case of skin toxicity related to MTX that affected the normal skin and spared the psoriatic plaques.
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Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Automedicação
/
Metotrexato
/
Toxidermias
/
Antagonistas do Ácido Fólico
/
Antimetabólitos Antineoplásicos
Tipo de estudo:
Guideline
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Dermatol Online J
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article