Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.
Dev Cell
; 18(6): 985-98, 2010 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-20627080
Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as "winners" or "losers." In Drosophila, the fwe locus produces three isoforms, fwe(ubi), fwe(Lose-A), and fwe(Lose-B). Basal levels of fwe(ubi) are constantly produced. During competition, the fwe(Lose) isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asas de Animais
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Canais de Cálcio
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Diferenciação Celular
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Apoptose
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Proteínas de Drosophila
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Drosophila melanogaster
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Espaço Extracelular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Dev Cell
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha