Synthesis and biological evaluation of indolyl chalcones as antitumor agents.
Bioorg Med Chem Lett
; 20(13): 3916-9, 2010 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-20627724
ABSTRACT
A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Chalconas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Índia