Variability of the melanocortin 1 receptor (MC1R) gene explains the segregation of the bronze locus in turkey (Meleagris gallopavo).
Poult Sci
; 89(8): 1599-602, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20634512
ABSTRACT
By sequencing the full coding region of the turkey melanocortin 1 receptor (MC1R) gene, we have found 4 mutations (c.96G > A, c.364A > T, c.450C > T, and c.887C > T) that are organized in 5 different haplotypes (MC1R*1 to MC1R*5). These haplotypes correlate perfectly with the 3 alleles of the bronze locus (i.e., B, b(+), and b(1)). We suggest that the dominant black phenotype, associated with the B allele, results from the constitutive activation of the receptor, an effect that might be mediated by the missense mutation c.364A > T (p.Ile122Phe). Moreover, we propose that the recessive black-winged bronze phenotype (linked to b(1)) might be produced by 2 deleterious mutations of MC1R (c.96G > A and c.887C > T). This is an unexpected finding because in mammals, MC1R deleterious polymorphisms are usually related with either red or lighter fur colors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Perus
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Variação Genética
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Segregação de Cromossomos
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Polimorfismo de Nucleotídeo Único
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Receptor Tipo 1 de Melanocortina
Limite:
Animals
Idioma:
En
Revista:
Poult Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha