Uterine changes during tamoxifen, toremifene, and other therapy for breast cancer: evaluation with magnetic resonance imaging.
Jpn J Radiol
; 28(6): 430-6, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20661693
ABSTRACT
PURPOSE:
We have performed pelvic magnetic resonance imaging (MRI) in patients undergoing breast cancer surgery before and after adjuvant drug therapy. Our purpose was to detect any radiographic uterine changes induced by various types of adjuvant therapy on pre- and postmenopausal patients by evaluating prospectively performed MRI. MATERIALS ANDMETHODS:
Between September 2004 and December 2007, a total of 41 women with breast cancer (11 premenopausal, 30 postmenopausal) were enrolled. All underwent MRI of the pelvis before and after drug therapy, and uterine changes were evaluated. Postoperative drugs used were selective estrogen receptor modulators (SERMs) including tamoxifen and toremifene (n = 18), aromatase inhibitors (n = 13), and anticancer drugs (n = 10).RESULTS:
Only the postmenopausal patients receiving SERMs showed a significant increase in endometrial thickness from 2.4 +/- 0.4 mm before therapy to 4.5 +/- 2.6 mm after therapy (P = 0.0485). No statistically significant endometrial change was evident in postmenopausal patients treated with aromatase inhibitors (P = 0.573) or anticancer drugs (P = 0.754). Also, in premenopausal patients treated with SERMs or anticancer drugs, the change in endometrial thickness was not statistically significant (P = 0.958, 0.370).CONCLUSION:
This prospective study using MRI has demonstrated that uterine changes associated with adjuvant drugs for breast cancer occur exclusively in postmenopausal patients receiving SERMs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tamoxifeno
/
Útero
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Neoplasias da Mama
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Toremifeno
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Pós-Menopausa
/
Moduladores Seletivos de Receptor Estrogênico
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Jpn J Radiol
Assunto da revista:
DIAGNOSTICO POR IMAGEM
/
RADIOLOGIA
/
RADIOTERAPIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Japão