Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice.
J Immunol
; 185(5): 2754-62, 2010 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-20675590
ABSTRACT
Zymosan is a complex fungal component shown to be capable of both promoting and suppressing the development of autoimmune disorders in mice. In this study, we show that a single injection of zymosan just prior to diabetes onset can significantly delay the progression of disease in NOD mice. Zymosan treatment of NOD mice induced the production of biologically active TGF-beta from cells infiltrating the pancreas and was associated with expansion of programmed cell death 1 ligand 1(+)TGF-beta(+) macrophages and Foxp3(+) regulatory T cells in vivo. Neutralization of either TGF-beta or programmed cell death 1 ligand 1 abrogated the protective effects of zymosan. Zymosan acted through TLR2 as well as ERK and p38 MAPK to induce macrophage secretion of TGF-beta and promotion of Foxp3(+) regulatory T cells in vitro and in vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Zimosan
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Glicoproteínas de Membrana
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Diferenciação Celular
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Fator de Crescimento Transformador beta
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Linfócitos T Reguladores
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Antígeno B7-1
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Proliferação de Células
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Diabetes Mellitus Tipo 1
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido