Discovery of biphenylketones as dual modulators of inflammation and bone loss.
Bioorg Med Chem Lett
; 20(18): 5548-51, 2010 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-20692834
ABSTRACT
Biphenylketones were identified as novel inhibitors of NFkappaB activation. Structure-activity studies led to the identification of compound 4c, which had good potency against osteoclasts (IC50=0.8 microM), showed oral activity, and was able to completely prevent inflammation and bone loss in vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Artrite
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Derivados de Benzeno
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Cetonas
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Anti-Inflamatórios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido