Lack of di-(2-ethylhexyl) phthalate activity in the C3H 10T 1 2 cell transformation system.
Toxicol In Vitro
; 1(1): 49-53, 1987.
Article
em En
| MEDLINE
| ID: mdl-20702379
The widely used plasticizer and rodent carcinogen di-(2-ethylhexyl) phthalate (DEHP) was examined for activity in the C3H 10T 1 2 murine fibroblast cell transformation system. Treatment with DEHP or its metabolite, mono-(2-ethylhexyl) phthalate, did not produce oncogenic transformation, initiate the process of transformation in cultures treated with a tumour promoter or promote the process of transformation in cultures pretreated with a chemical carcinogen. These findings are consistent with the suggestion that the carcinogenicity of DEHP is mediated by an indirect mechanism and not by covalent interaction of DEHP with DNA.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Toxicol In Vitro
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Estados Unidos