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Human respiratory syncytial virus in children with acute respiratory tract infections in China.
Zhang, Rong-Fang; Jin, Yu; Xie, Zhi-Ping; Liu, Na; Yan, Kun-Long; Gao, Han-Chun; Song, Jing-Rong; Yuan, Xin-Hui; Xiao, Ni-Guang; Guo, Ming-Wei; Zhou, Qiong-Hua; Hou, Yun-De; Duan, Zhaojun.
Afiliação
  • Zhang RF; School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China.
J Clin Microbiol ; 48(11): 4193-9, 2010 Nov.
Article em En | MEDLINE | ID: mdl-20810776
ABSTRACT
There are limited data on the prevalence and clinical and molecular characterization of human respiratory syncytial virus (HRSV) in children with acute respiratory tract infections (ARTIs) in China. From December 2006 to March 2009, 894 nasopharyngeal aspirates (NPAs) were collected from children under 14 years of age with ARTIs. Samples were screened for HRSV and genotyped by reverse transcription-PCR (RT-PCR) and sequencing. Demographic and clinical information was recorded. A total of 38.14% (341/894) of samples were positive for HRSV. Phylogenetic analysis revealed that 60.4% of the selected 227 RSV strains were GA2, 34.4% were BA, 4.8% were GB2, and 0.4% were GB3. A total of 40.47% of all of the RSV-positive samples were coinfected with other respiratory viruses, and adenovirus was the most common additional respiratory virus. No statistical differences were found in the frequency of diagnosis and symptoms between the coinfection group and monoinfection group. Additionally, no statistical differences were found in epidemiological characterizations or disease severity between genotype BA- and GA2-positive patients, except for a greater frequency of lower respiratory tract infections (LRTIs) (mostly bronchitis)with BA. HRSV is the most important viral pathogen in Chinese children with ARTIs. Four genotypes (i.e., GA2, BA, GB2, and GB3) circulate locally, and the predominant genotype may shift between seasons. Coinfection with other viruses does not affect disease severity. HRSV genotypes were not associated with different epidemiological characterizations or disease severity.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: Asia Idioma: En Revista: J Clin Microbiol Ano de publicação: 2010 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: Asia Idioma: En Revista: J Clin Microbiol Ano de publicação: 2010 Tipo de documento: Article País de afiliação: China