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Clinical syndromes and consequences of antiretroviral-related hepatotoxicity.
Núñez, Marina.
Afiliação
  • Núñez M; Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA. mnunez@wfubmc.edu
Hepatology ; 52(3): 1143-55, 2010 Sep.
Article em En | MEDLINE | ID: mdl-20812358
Highly active antiretroviral therapy (HAART)-related hepatotoxicity complicates the management of patients infected with human immunodeficiency virus (HIV), increases medical costs, alters the prescription patterns, and affects the guideline recommendations. Among the clinical consequences derived from HAART-related liver toxicity, hypersensitivity reactions and lactic acidosis are recognized as acute events with potential to evolve into fatal cases, whereas there seems to be other syndromes not as well characterized but of equal concern as possible long-term liver complications. Belonging to the latter category of syndrome, HAART-related nonalcoholic steatohepatitis, liver fibrosis, portal hypertension, and nodular regenerative hyperplasia are discussed in this review. Updated information on liver toxicity of current antiretroviral drugs, including the most recently licensed, is provided. Management and prevention of liver toxicity among HIV-infected patients treated with HAART are reviewed as well.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Terapia Antirretroviral de Alta Atividade / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Etiology_studies / Guideline / Risk_factors_studies Limite: Humans Idioma: En Revista: Hepatology Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Terapia Antirretroviral de Alta Atividade / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Etiology_studies / Guideline / Risk_factors_studies Limite: Humans Idioma: En Revista: Hepatology Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos