Separating the good and evil of cardiac growth by CIB1 and calcineurin.
Cell Metab
; 12(3): 205-6, 2010 Sep 08.
Article
em En
| MEDLINE
| ID: mdl-20816084
ABSTRACT
Ca(2+)-calcineurin-NFAT signaling plays a major role in promoting pathological cardiac hypertrophy. Heineke et al. (2010) show that CIB1 strongly enhances calcineurin activation and cardiac hypertrophy upon pathological stress, likely by functioning as a scaffold protein that exposes calcineurin to the L-Type Ca(2+) channel and the sarcolemma.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Cell Metab
Assunto da revista:
METABOLISMO
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos