Oleanane-type triterpene glucuronides from the roots of Glycyrrhiza uralensis Fischer.
Planta Med
; 76(13): 1457-63, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20857541
ABSTRACT
Investigation of characteristic constituents of the roots of Glycyrrhiza uralensis Fischer led to isolation of four new triterpene glucuronides, namely uralsaponins C-F (1-4), an artificial product, namely the methyl ester of glycyrrhizin (5), as well as six known triterpene glucuronides (6-11). These new compounds were identified by 1D and 2D NMR spectroscopic analysis. The cytotoxicity of the selected compounds and their aglycones were evaluated against HeLa and MCF-7 cancer cell lines, and the preliminary structure-activity relationship was also elucidated.
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Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Extratos Vegetais
/
Glycyrrhiza
/
Neoplasias
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China