Latency of herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T cells.
J Med Virol
; 82(11): 1917-20, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20872719
ABSTRACT
Herpes simplex virus type-1 latency and CD8+ T-cell occurrence were investigated in the trigeminal, geniculate, and vestibular ganglia from seven deceased humans. The HSV-1 "latency-associated transcript" was assessed by in situ hybridization and quantitative RT-PCR. Infiltration of CD8+ T cell was detected by immunohistochemistry and quantitative RT-PCR. The data show that HSV-1 latency and CD8+ T-cell infiltration are not solely confined to the trigeminal ganglia but can also occur in other cranial ganglia along the neuroaxis. However, the HSV-1 latency transcripts in the geniculate and vestibular ganglia were expressed at a very low level. The difference in CD8 transcript levels among HSV-1 latently infected trigeminal ganglia, geniculate, and vestibular ganglia was less conspicuous. Colocalization of latent HSV-1 and CD8+ T cells in geniculate and vestibular ganglia supports further the hypothesis that HSV-1 reactivation is possible in these ganglia and is the cause of Bell's palsy and vestibular neuritis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nervo Vestibular
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Latência Viral
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Herpesvirus Humano 1
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Linfócitos T CD8-Positivos
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MicroRNAs
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Gânglio Geniculado
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Child
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Child, preschool
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Humans
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Infant
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Middle aged
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha