Development of an active targeting liposome encapsulated with high-density colloidal gold for transmission electron microscopy.
J Electron Microsc (Tokyo)
; 60(1): 95-9, 2011.
Article
em En
| MEDLINE
| ID: mdl-20923872
ABSTRACT
Active targeting of the liposome is an attractive strategy for drug delivery and in vivo bio-imaging. We previously reported the specific accumulation of Sialyl Lewis X (SLX) liposome to inflamed tissue in arthritic model mice or tumor-bearing mice. SLX-liposome encapsulation with fluorescent substances allows for the visualization of these liposomes by the time-dependent transvascular accumulation of fluorescent signals in the histological sections. In the present study, we developed a new SLX-liposome encapsulated with colloidal gold for transmission electron microscopic observation. We herein describe the characterization of the colloidal gold-loaded SLX-liposomes and demonstrate its specific targeting to the endothelial cells of tumor blood vessels in tumor-bearing mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Coloide de Ouro
/
Células Endoteliais
/
Microscopia Eletrônica de Transmissão
/
Lipossomos
/
Neoplasias
Limite:
Animals
Idioma:
En
Revista:
J Electron Microsc (Tokyo)
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão