In vivo imaging biomarkers in mouse models of Alzheimer's disease: are we lost in translation or breaking through?
Int J Alzheimers Dis
; 20102010 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-20953404
ABSTRACT
Identification of biomarkers of Alzheimer's Disease (AD) is a critical priority to efficiently diagnose the patients, to stage the progression of neurodegeneration in living subjects, and to assess the effects of disease-modifier treatments. This paper addresses the development and usefulness of preclinical neuroimaging biomarkers of AD. It is today possible to image in vivo the brain of small rodents at high resolution and to detect the occurrence of macroscopic/microscopic lesions in these species, as well as of functional alterations reminiscent of AD pathology. We will outline three different types of imaging biomarkers that can be used in AD mouse models biomarkers with clear translational potential, biomarkers that can serve as in vivo readouts (in particular in the context of drug discovery) exclusively for preclinical research, and finally biomarkers that constitute new tools for fundamental research on AD physiopathogeny.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Int J Alzheimers Dis
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França