Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo.

Foligné, Benoît; Deutsch, Stéphanie-Marie; Breton, Jérôme; Cousin, Fabien J; Dewulf, Joëlle; Samson, Michel; Pot, Bruno; Jan, Gwénaël

Foligné, Benoît; Deutsch, Stéphanie-Marie; Breton, Jérôme; Cousin, Fabien J; Dewulf, Joëlle; Samson, Michel; Pot, Bruno; Jan, Gwénaël.

Afiliação

Foligné B; Institut Pasteur de Lille, Lactic Acid Bacteria & Mucosal Immunity, Center for Infection and Immunity of Lille, 1, Rue du Pr Calmette, BP 245, F-59019 Lille, France.

Appl Environ Microbiol ; 76(24): 8259-64, 2010 Dec.

Article em En | MEDLINE | ID: mdl-20971874

ABSTRACT

ABSTRACT

Immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (PBMCs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (IL-10). Two selected strains of Propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria.

Assuntos

Fatores Imunológicos/farmacologia; Probióticos/farmacologia; Propionibacterium/imunologia; Propionibacterium/fisiologia; Animais; Células Cultivadas; Colite/prevenção & controle; Modelos Animais de Doenças; Humanos; Interleucina-10/metabolismo; Leucócitos Mononucleares/imunologia; Leucócitos Mononucleares/microbiologia; Camundongos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propionibacterium / Probióticos / Fatores Imunológicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Appl Environ Microbiol Ano de publicação: 2010 Tipo de documento: Article País de afiliação: França

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