Generation of new mouse sarcoma viruses in cell culture.
Science
; 201(4358): 821-4, 1978 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-210501
ABSTRACT
Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Retroviridae
/
Sarcoma Experimental
/
Transformação Celular Neoplásica
/
Genes Virais
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1978
Tipo de documento:
Article