1,2,5-Oxadiazole analogues of leflunomide and related compounds.
Eur J Med Chem
; 46(1): 383-92, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-21109332
ABSTRACT
A new series of compounds, structurally related to leflunomide, based on the 1,2,5-oxadiazole ring system (furazan) has been synthesised, and their ability to undergo ring scission at physiological pH to afford the corresponding cyano-oximes has been analyzed. The latter, together with the respective nitro derivatives obtained by oxidation, have been characterised as weak inhibitors of rat dihydroorotate dehydrogenase (DHODH).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
/
Inibidores Enzimáticos
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Isoxazóis
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Itália