Estimating pediatric inpatient medication use in the United States.
Pharmacoepidemiol Drug Saf
; 20(1): 76-82, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-21182155
ABSTRACT
PURPOSE:
We demonstrated the feasibility of developing national estimates of pediatric inpatient medication use by analyzing data from a large administrative database.METHODS:
Pediatric inpatient data were extracted from Premier Perspective® database to calculate the prevalence of use of specific medications among hospitalized children in 2008. The database was validated by comparing characteristics to the HCUP KID sample of pediatric hospitalizations for 2006. Prevalence was calculated by categorizing patients as ever or never having received a specific drug.RESULTS:
The 10 drugs administered in the most pediatric hospitalizations were acetaminophen, lidocaine, ampicillin, gentamicin, fentanyl, ibuprofen, morphine, ondansetron, ceftriaxone, and albuterol.CONCLUSIONS:
Although the database is not a probability-based sample, it bears sufficient similarity to a probability-based sample of pediatric hospitalizations (HCUP KID) to serve as a starting point in developing national estimates of inpatient pediatric medication use. Over 500 drug entities were administered to hospitalized children, but most are used by small percentages of hospitalized patients. The small numbers of children using any one drug has implications for efforts to study efficacy and safety, describe off-label use, monitor adverse events, describe practice, and conduct comparative effectiveness research.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Uso de Medicamentos
/
Hospitalização
/
Pacientes Internados
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Pharmacoepidemiol Drug Saf
Assunto da revista:
EPIDEMIOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos