Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium.
J Infect Dis
; 203(3): 401-5, 2011 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-21186258
ABSTRACT
Salmonella meningitis is a serious disease of the central nervous system, common particularly in Africa. Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (hBMECs), the single-cell layer constituting the blood-brain barrier (BBB). Cellular invasion was dependent on host actin cytoskeleton rearrangements, while expression of a functional type III secretion system was not essential. In addition, Salmonella infection activated a proinflammatory immune response targeting neutrophil signaling and recruitment. Salmonella invasion and immune activation may represent a crucial step in the penetration of the BBB and development of Salmonella meningitis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Endotélio Vascular
Limite:
Humans
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos