Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency.
Int Orthop
; 35(11): 1633-7, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21221577
ABSTRACT
PURPOSE:
The aim of this study was to determine the value of systemic biochemical markers of bone turnover-urine levels of cross-linked C-terminal telopeptide I (uCTX-I), urinary C-terminal telopeptide II (uCTX-II) and serum cartilage oligomeric matrix protein (sCOMP)-in the diagnosis of chondral defects after anterior cruciate ligament (ACL) rupture. Thirty-eight patients with previous ACL rupture were included.METHODS:
Magnetic resonance imaging (MRI) of the injured and the intact knee joint was performed with volumetric measurement of volume and area of cartilage (VC/AC), area of subchondral bone (cAB), and area of subchondral bone denuded and eroded (dAB). Biochemical markers were measured using commercially available enzyme-linked immunoassays.RESULTS:
MRI-based volumetric cartilage measurement showed significant differences between the injured and the intact knees. uCTX-I, sCOMP and in parts uCTX-II correlated well with MRI parameters. CTX-I showed a significant correlation with VC and AC of the whole knee joint.CONCLUSIONS:
The results suggest that uCTX-I, uCTX-II and sCOMP could identify patients with focal cartilage lesions from an early stage of osteoarthritis of the knee.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Glicoproteínas
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Ligamento Cruzado Anterior
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Proteínas da Matriz Extracelular
/
Colágeno Tipo I
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Colágeno Tipo II
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Traumatismos do Joelho
/
Articulação do Joelho
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Int Orthop
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha