[Comparisons of efficacy and safety of tolterodine and oxybutynin in children with idiopathic overactive bladder].
Zhongguo Dang Dai Er Ke Za Zhi
; 13(1): 26-8, 2011 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-21251382
ABSTRACT
OBJECTIVE:
To compare the efficacy and safety of tolterodine and oxybutynin in the treatment of idiopathic overactive bladder in children.METHODS:
A total of 204 children with idiopathic overactive bladder were randomly divided into three groups (n=68 each) placebo, tolterodine-treated and oxybutynin-treated. The efficacy and safety were evaluated two weeks after treatment.RESULTS:
The effective rate was 25% in the placebo group, 89% in the tolterodine-treated group, and 92% in the oxybutynin-treated group. The effective rate in the two treatment groups was significantly higher than that in the placebo group (P<0.05). There was a similar efficacy between the two treatment groups. The incidence of adverse events in the tolterodine-treated group (28%) was significantly lower than that in the oxybutnin-treated group (57%) (P<0.05).CONCLUSIONS:
Tolterodine has a similar efficacy to oxybutynin in the treatment of idiopathic overactive bladder in children, with better safety in pharmacotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Fenilpropanolamina
/
Compostos Benzidrílicos
/
Antagonistas Muscarínicos
/
Cresóis
/
Bexiga Urinária Hiperativa
/
Ácidos Mandélicos
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China