Mitochondrial capture by a transmissible cancer.
Science
; 331(6015): 303, 2011 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-21252340
ABSTRACT
Canine transmissible venereal tumor (CTVT) is an infectious cell line circulating in many feral dog populations. It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tumores Venéreos Veterinários
/
Doenças do Cão
/
Genoma Mitocondrial
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido