Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse.
Compr Psychiatry
; 52(2): 188-94, 2011.
Article
em En
| MEDLINE
| ID: mdl-21295226
ABSTRACT
OBJECTIVE:
Preclinical and human family studies clearly link monoamine oxidase A (MAOA) to aggression and antisocial personality (ASP). The 30-base pair variable number tandem repeat in the MAOA promoter regulates MAOA levels, but its effects on ASP in humans are unclear.METHODS:
We evaluated the association of the variable number tandem repeat of the MAOA promoter with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, ASP disorder (ASPD) traits in a community sample of 435 participants from the Hopkins Epidemiology of Personality Disorders Study.RESULTS:
We did not find an association between the activity of the MAOA allele and ASPD traits; however, among whites, when subjects with a history of childhood physical abuse were excluded, the remaining subjects with low-activity alleles had ASPD trait counts that were 41% greater than those with high-activity alleles (P < .05).CONCLUSION:
The high-activity MAOA allele is protective against ASP among whites with no history of physical abuse, lending support to a link between MAOA expression and antisocial behavior.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Monoaminoxidase
/
Transtorno da Personalidade Antissocial
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Compr Psychiatry
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos