[Study on pharmacokinetics of phillyrin in Shuanghuanglian for injection].

ABSTRACT

OBJECTIVE: To study the plasma concentration and pharmacokinetics of phillyrin in Shuanghuanglian for injection in rats. METHODS: SD rats were given Shuanghuanglian for injection by iv, blood samples were collected at different time. The phillyrin concentration in plasma was determined by RP-HPLC. The parameters of pharmacokinetics were analyzed by program DAS 2.0. RESULTS: The main pharmacokinetics parameters of phillyrin in ratst1/2 (alpha) (0.44 +/- 0.06) h, t1/2 (beta) (2.77 +/- 0.36) h, V1 (0.09 +/- 0.01) L/kg, CL (0.09 +/- 0.007) L/(h x kg), AUC0-1, (5.56 +/- 0.47 mg x h/L), AUC0-infinity (6.44 +/- 0.53) mg x h/L. CONCLUSION: Phillyrin has two compartment model in rats, the pharmacokinetics of phillyrin characteristic is a process of rapid dispatching and slow elimination in rats.