[Study on pharmacokinetics of phillyrin in Shuanghuanglian for injection].
Zhong Yao Cai
; 33(10): 1602-5, 2010 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-21355201
ABSTRACT
OBJECTIVE:
To study the plasma concentration and pharmacokinetics of phillyrin in Shuanghuanglian for injection in rats.METHODS:
SD rats were given Shuanghuanglian for injection by iv, blood samples were collected at different time. The phillyrin concentration in plasma was determined by RP-HPLC. The parameters of pharmacokinetics were analyzed by program DAS 2.0.RESULTS:
The main pharmacokinetics parameters of phillyrin in ratst1/2 (alpha) (0.44 +/- 0.06) h, t1/2 (beta) (2.77 +/- 0.36) h, V1 (0.09 +/- 0.01) L/kg, CL (0.09 +/- 0.007) L/(h x kg), AUC0-1, (5.56 +/- 0.47 mg x h/L), AUC0-infinity (6.44 +/- 0.53) mg x h/L.CONCLUSION:
Phillyrin has two compartment model in rats, the pharmacokinetics of phillyrin characteristic is a process of rapid dispatching and slow elimination in rats.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Forsythia
/
Glucosídeos
/
Anti-Inflamatórios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Zhong Yao Cai
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China