The shortest synthetic route to puromycin analogues using a modified Robins approach.
J Org Chem
; 76(7): 2253-6, 2011 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-21361316
ABSTRACT
We are reporting on the utility of commercial vinyl isocyanate for a practical synthetic route from adenosine to N(6)-bis-demethylpuromycin in seven steps and 65% overall yield. A clean one-pot conversion of 3'-bromo-2'-carbamoyl derivative 8 to 3'-amino-3'-deoxyadenosine derivative 10 is the main feature of this synthetic pathway. This synthesis is the shortest synthetic route toward 3'-(aminoacylamido)deoxyadenosines to date.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Puromicina
/
Desoxiadenosinas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França