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Glucokinase-activating sesquinlignans from the rhizomes of Acorus tatarinowii Schott.
Ni, Gang; Shen, Zhu-Fang; Lu, Yang; Wang, Ying-Hong; Tang, Yan-Bo; Chen, Ruo-Yun; Hao, Zhi-You; Yu, De-Quan.
Afiliação
  • Ni G; The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Beijing 100050, P. R. China.
J Org Chem ; 76(7): 2056-61, 2011 Apr 01.
Article em En | MEDLINE | ID: mdl-21366319
Three novel sesquinlignans, tatanans A (1), B (2), and C (3), have been isolated from the rhizomes of Acorus tatarinowii Schott. Their structures were established by spectroscopic techniques and single-crystal X-ray analysis. Tatanans A-C potently increase GK enzymatic activity with EC(1.5) values in the range of 0.16-1.85 µM. The potent GK activity and unique structural features of tatanans make them promising leads for therapeutic development of antihyperglycemic drugs.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lignanas / Acorus / Rizoma / Glucoquinase Idioma: En Revista: J Org Chem Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lignanas / Acorus / Rizoma / Glucoquinase Idioma: En Revista: J Org Chem Ano de publicação: 2011 Tipo de documento: Article