Second messengers and membrane trafficking direct and organize growth cone steering.
Nat Rev Neurosci
; 12(4): 191-203, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21386859
ABSTRACT
Graded distributions of extracellular cues guide developing axons toward their targets. A network of second messengers - Ca(2+) and cyclic nucleotides - shapes cue-derived information into either attractive or repulsive signals that steer growth cones bidirectionally. Emerging evidence suggests that such guidance signals create a localized imbalance between exocytosis and endocytosis, which in turn redirects membrane, adhesion and cytoskeletal components asymmetrically across the growth cone to bias the direction of axon extension. These recent advances allow us to propose a unifying model of how the growth cone translates shallow gradients of environmental information into polarized activity of the steering machinery for axon guidance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Sistemas do Segundo Mensageiro
/
Fenômenos Fisiológicos Celulares
/
Cones de Crescimento
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Rev Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão