Supramolecular complexing of membane Siglec CD22 mediated by a polyvalent heterobifunctional ligand that templates on IgM.
Bioconjug Chem
; 22(4): 546-50, 2011 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-21405019
ABSTRACT
We report the synthesis and in vitro evaluation of a multivalent homing device, a polymer which contains preordered pendant groups with dual specificity, a trisaccharide moiety, which is specific for the siglec CD22, and an antibody specific hapten, nitrophenol. The device efficiently attracts antihapten IgM to the surface of human lymphoma B cells as well as to CD22-conjugated magnetic beads by mediating the formation of a ternary complex on the surface of the target.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina M
/
Lectina 2 Semelhante a Ig de Ligação ao Ácido Siálico
Limite:
Humans
Idioma:
En
Revista:
Bioconjug Chem
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Canadá