Your browser doesn't support javascript.
loading
Genetic variation in complement component C3 shows association with ischaemic stroke.
Olsson, S; Stokowska, A; Holmegaard, L; Jood, K; Blomstrand, C; Pekna, M; Jern, C.
Afiliação
  • Olsson S; Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. sandra.olsson@neuro.gu.se
Eur J Neurol ; 18(10): 1272-4, 2011 Oct.
Article em En | MEDLINE | ID: mdl-21414106
ABSTRACT
BACKGROUND AND

PURPOSE:

The aim of this study was to investigate whether genetic variation at the third complement component (C3) locus is associated with ischaemic stroke (IS).

METHODS:

The Sahlgrenska Academy Study on Ischaemic Stroke comprises 844 patients with IS, and 668 healthy controls. Sixteen SNPs were analyzed.

RESULTS:

Two SNPs, rs2277984 and rs3745565, showed a significant association with overall IS. The SNP rs2277984 also showed association with the IS subtype cryptogenic stroke. These associations were independent of hypertension, diabetes, and smoking. The independent association between rs3745565 and overall IS withstands correction for multiple testing.

CONCLUSION:

In this sample of patients with IS, genetic variation in C3 is associated with IS.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complemento C3 / Isquemia Encefálica / Predisposição Genética para Doença / Acidente Vascular Cerebral Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Eur J Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Suécia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complemento C3 / Isquemia Encefálica / Predisposição Genética para Doença / Acidente Vascular Cerebral Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Eur J Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Suécia