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B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.
Salek-Ardakani, Samira; Choi, Youn Soo; Rafii-El-Idrissi Benhnia, Mohammed; Flynn, Rachel; Arens, Ramon; Shoenberger, Stephen; Crotty, Shane; Croft, Michael; Salek-Ardakani, Shahram.
Afiliação
  • Salek-Ardakani S; Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA.
J Immunol ; 186(9): 5294-303, 2011 May 01.
Article em En | MEDLINE | ID: mdl-21441451
Follicular Th (T(FH)) cells are specialized in provision of help to B cells that is essential for promoting protective Ab responses. CD28/B7 (B7-1 and B7-2) interactions are required for germinal center (GC) formation, but it is not clear if they simply support activation of naive CD4 T cells during initiation of responses by dendritic cells or if they directly control T(FH) cells and/or directly influence follicular B cell differentiation. Using a model of vaccinia virus infection, we show that B7-2 but not B7-1 deficiency profoundly impaired T(FH) cell development but did not affect CD4 T cell priming and Th1 differentiation. Consistent with this, B7-2 but not B7-1 was required for acquisition of GC B cell phenotype, plasma cell generation, and virus-specific neutralizing Ab responses. Mixed adoptive transfer experiments indicated that bidirectional interactions between CD28 expressed on activated T cells and B7-2 expressed on follicular B cells were essential for maintenance of the T(FH) phenotype and GC B cell development. Our data provide new insight into the source and nature of molecules required for T(FH) cells to direct GC B cell responses.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacínia / Linfócitos B / Ativação Linfocitária / Linfócitos T Auxiliares-Indutores / Antígeno B7-2 Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacínia / Linfócitos B / Ativação Linfocitária / Linfócitos T Auxiliares-Indutores / Antígeno B7-2 Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos