Angustimine and angustifolimine: two new alkaloids from Daphniphyllum angustifolium.

Zhang, Chuan-Rui; Fan, Cheng-Qi; Dong, Shi-Hui; Liu, Hong-Bing; Zhou, Wen-Bin; Wu, Yan; Yue, Jian-Min

Zhang, Chuan-Rui; Fan, Cheng-Qi; Dong, Shi-Hui; Liu, Hong-Bing; Zhou, Wen-Bin; Wu, Yan; Yue, Jian-Min.

Afiliação

Zhang CR; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

Org Lett ; 13(9): 2440-3, 2011 May 06.

Article em En | MEDLINE | ID: mdl-21469700

ABSTRACT

ABSTRACT

Two new alkaloids, angustimine (1) featuring an unprecedented skeleton, and angustifolimine (2) being a rare diamino Daphniphyllum alkaloid, were isolated from Daphniphyllum angustifolium. Their structures were elucidated by extensive spectroscopic analysis. The biosynthetic origin of 1 was postulated. Cytotoxic activities of 1 and 2 were tested, and all of them were inactive.

Assuntos

Alcaloides/química; Magnoliopsida/química; Alcaloides/isolamento & purificação; Alcaloides/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Humanos; Modelos Moleculares; Estrutura Molecular

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Magnoliopsida / Alcaloides Limite: Humans Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2011 Tipo de documento: Article

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