Lethal tuberculosis in a previously healthy adult with IL-12 receptor deficiency.
J Clin Immunol
; 31(4): 537-9, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21487897
ABSTRACT
A 33-year-old man was admitted in hospital due to fever, generalized lymphadenopathy, and hepatosplenomegaly. He had a history of anti-tuberculosis treatment in the previous 3 years. Despite normal chest radiograph, a sputum sample was smear-positive for acid-fast bacilli, and polymerase chain reaction was positive for Mycobacterium tuberculosis complex. Drug susceptibility test revealed resistance to isoniazid and rifampin. Evaluation of the patient's immune system revealed IL-12Rß1 deficiency. The patient died of disseminated tuberculosis (TB), despite appropriate antibiotic treatment. This is the first IL-12 receptor-deficient patient presenting with disseminated TB in adulthood, without any previous relevant medical history. This diagnosis should be considered in selected adult patients with unexplained, overwhelming TB. IL-12Rß1 deficiency is a genetic etiology of severe TB in adults and should be considered in adult patients with disseminated TB.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Receptores de Interleucina-12
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Immunol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Irã