Assembly of bacterial ribosomes.
Annu Rev Biochem
; 80: 501-26, 2011.
Article
em En
| MEDLINE
| ID: mdl-21529161
ABSTRACT
The assembly of ribosomes from a discrete set of components is a key aspect of the highly coordinated process of ribosome biogenesis. In this review, we present a brief history of the early work on ribosome assembly in Escherichia coli, including a description of in vivo and in vitro intermediates. The assembly process is believed to progress through an alternating series of RNA conformational changes and protein-binding events; we explore the effects of ribosomal proteins in driving these events. Ribosome assembly in vivo proceeds much faster than in vitro, and we outline the contributions of several of the assembly cofactors involved, including Era, RbfA, RimJ, RimM, RimP, and RsgA, which associate with the 30S subunit, and CsdA, DbpA, Der, and SrmB, which associate with the 50S subunit.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ribossomos
/
Proteínas de Escherichia coli
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos