Dietary immunomodulatory factors in the development of immune tolerance.
Curr Allergy Asthma Rep
; 11(4): 325-33, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21538229
ABSTRACT
Emerging evidence suggests that exposures during pregnancy and the early postnatal period can modify gene expression and disease propensity. Diet is a major environmental exposure, and dietary factors, including polyunsaturated fatty acids, probiotics, oligosaccharides, antioxidants, folate, and other vitamins, have effects on immune function. Some also have been implicated in reduced risk of allergy in observational studies. Intervention trials with polyunsaturated fatty acids, probiotics, and oligosaccharides suggest preliminary but as-of-yet-unconfirmed benefits. Food allergen avoidance during pregnancy, lactation, or infancy has provided no consistent evidence in allergy prevention and is no longer recommended. Rather, there is now a focus on food allergens in tolerance induction. Specific nutrients can induce changes in gene expression during early development and have been implicated in potentially heritable "epigenetic" changes in disease predisposition. Collectively, these observations emphasize that early exposures may modify tolerance development and that further research on these exposures should remain a priority.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Alérgenos
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Dieta
/
Hipersensibilidade
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Tolerância Imunológica
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Fatores Imunológicos
/
Troca Materno-Fetal
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Animals
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Female
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Humans
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Male
/
Pregnancy
Idioma:
En
Revista:
Curr Allergy Asthma Rep
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Suécia