Synthetic studies on neoclerodane diterpenes from Salvia splendens: oxidative modifications of ring A.
Tetrahedron
; 65(8): 1708-1715, 2009 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-21544261
ABSTRACT
Salvinorin A (1), a neoclerodane diterpene from the hallucinogenic mint Salvia divinorum, is the only known naturally occurring non-nitrogenous and specific κ-opioid agonist. Some oxidative modifications of the A ring in the congeners of 1 isolated from Salvia splendens salviarin, splenolide B, splendidin and in the non-natural 8-epi-salviarin gave new derivatives, some of which were tested as agonists at opioid receptors. However, none of these compounds were active. The presence of the C-18, C-19 lactone could be at the origin of the observed lack of binding affinity.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália