Cross-resistance to antineoplastic agents in a human small-cell lung-cancer subline resistant to okadaic Acid.
Oncol Rep
; 2(5): 705-10, 1995 Sep.
Article
em En
| MEDLINE
| ID: mdl-21597801
ABSTRACT
We report on a human small cell lung cancer subline (H69/OA100) resistant to okadaic acid, an inhibitor of protein phosphatases. H69/OA100 showed cross-resistance to cis-diamminedichloroplatinum(II) (CDDP), adriamycin, and vinca alkaloids. Intracellular retention of adriamycin and CDDP in H69/OA100 was the same as those in H69. H69/OA100 was not shown to express MDR-1 by the reverse transcription polymerase chain reaction method. Expression level of mRNA of multidrug resistance-associated protein (MRP) in H69/OA100 was the same as that in H69. These data suggest that the mechanism of drug resistance in H69/OA100 might be due to a new mechanism of non-P-glycoprotein mediated multidrug resistance.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Japão