αvß3-Integrin-targeting lanthanide complex: synthesis and evaluation as a tumor-homing luminescent probe.
Bioorg Med Chem Lett
; 21(12): 3515-8, 2011 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-21600766
ABSTRACT
The application of lanthanide complexes in the time-resolved fluorescence imaging of living cells has emerged in the last few decades, providing high-contrast images of cells through detection of the delayed emission. In the present study, we synthesized novel trivalent lanthanide complexes containing the cyclic peptide c(RGDfK) to visualize the α(v)ß(3)-integrin-expressing tumor cells. Conjugation of c(RGDfK) with the macrocyclic bipyridine ligand had little effect on the fluorescence properties of the complex, indicating that the coordinated lanthanide ion was well isolated from the peptide. Bright luminescence images of α(v)ß(3)-integrin-expressing U87-MG cells were successfully obtained by employing the probes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Elementos da Série dos Lantanídeos
/
Integrina alfaVbeta3
/
Substâncias Luminescentes
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão