Deoxynivalenol transport across the human placental barrier.
Food Chem Toxicol
; 49(9): 2046-52, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21620924
ABSTRACT
Deoxynivalenol (DON) is the most commonly detected mycotoxin contaminant of cereal crops and cereal based food products in temperate regions of the world. DON causes adverse health effects in animals, passes through to the foetus and causes foetal abnormalities in animals. Biomonitoring for DON has revealed frequent human exposure. This study reports on DON transfer across the human placenta. Firstly, in vitro studies with the BeWo b30 clone were used as a rapid screening model showing transfer of DON through a stable confluent cell monolayer. Five term placentas were then used to study DON transfer with the ex vivo dual perfusion model. The concentration of DON on the foetal side after 4h was about 21% of that on the maternal side at t=0. These results support the data from the BeWo monolayer model in respect to the transport rate of DON, and are consistent with our hypothesis of foetal exposure to DON during pregnancy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Tricotecenos
/
Troca Materno-Fetal
/
Micotoxinas
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Dinamarca