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A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice.
Lin, Wenyao; Fan, Huiying; Cheng, Xiaoliang; Ye, Yu; Chen, Xiaowei; Ren, Tao; Qi, Wenbao; Liao, Ming.
Afiliação
  • Lin W; Key Laboratory of Animal Disease Control and Prevention of the Ministry of Agriculture, Guangzhou, China.
Virol J ; 8: 273, 2011 Jun 04.
Article em En | MEDLINE | ID: mdl-21639929
BACKGROUND: Avian influenza viruses of H9N2 subtype have become highly prevalent in avian species. Although these viruses generally cause only mild to moderate disease, they can infect a wide variety of species, including chickens, quail, turkeys, ducks, geese, pheasant, partridge, and pigeon, even transmitted to mammalian species, including humans, accelerating the efforts to devise protective strategies against them. RESULTS: The results showed that stronger immune responses were induced in a mouse model immunized with BV-Dual-HA than in those vaccinated with a DNA vaccine encoding the same antigen. Moreover, complete protection against lethal challenge with H9N2 virus was observed in mice. CONCLUSION: BV-Dual-HA could be utilized as a vaccine candidate against H9N2 virus infection.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Baculoviridae / Infecções por Orthomyxoviridae / Glicoproteínas de Hemaglutininação de Vírus da Influenza / Vírus da Influenza A Subtipo H9N2 / Vetores Genéticos / Antígenos Virais Limite: Animals Idioma: En Revista: Virol J Assunto da revista: VIROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Baculoviridae / Infecções por Orthomyxoviridae / Glicoproteínas de Hemaglutininação de Vírus da Influenza / Vírus da Influenza A Subtipo H9N2 / Vetores Genéticos / Antígenos Virais Limite: Animals Idioma: En Revista: Virol J Assunto da revista: VIROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: China