Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance.
Molecules
; 16(6): 4828-35, 2011 Jun 10.
Article
em En
| MEDLINE
| ID: mdl-21666549
ABSTRACT
Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones Apigenine, genkwanine, 7,4'-dimethylapigenin, trimethylapigenin, cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance. This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4',5,6,7 tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
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Flavonoides
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Asteraceae
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Farmacorresistência Bacteriana
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Antibacterianos
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil