Ideal versus corrected body weight for dosage of sugammadex in morbidly obese patients.
Anaesthesia
; 66(8): 721-5, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21692760
ABSTRACT
To date, the dosing of sugammadex is based on real body weight without taking fat content into account. We compared the reversal of profound rocuronium-induced neuromuscular blockade in morbidly obese patients using doses of sugammadex based on four different weight corrections. One hundred morbidly obese patients, scheduled for laparoscopic bariatric surgery under propofol-sufentanil anaesthesia, were randomly assigned four groups ideal body weight; ideal body weight + 20%; ideal body weight + 40%; and real body weight. Patients received sugammadex 2 mg.kg(-1), when adductor pollicis monitoring showed two responses. The primary endpoint was full decurarisation. Secondary endpoints were the ability to get into bed independently on arrival to the post-anaesthetic care unit and clinical signs of residual paralysis. There was no residual paralysis in any patient. Morbidly obese patients can safely be decurarised from rocuronium-induced neuromuscular blockade T1-T2 with sugammadex dosed at 2 mg.kg(-1) ideal body weight + 40% (p < 0.0001).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peso Corporal
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Obesidade Mórbida
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Gama-Ciclodextrinas
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anaesthesia
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Bélgica