Antimicrobial, cytotoxic lignans and terpenoids from the twigs of Pseudolarix kaempferi.
Planta Med
; 77(17): 1924-31, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21728150
ABSTRACT
Seven new compounds, including four lignans, (+)-(8S,8'S)-9,9'-dibenzoylsecoisolariciresinol (1), (+)-(8S*,8'R*)-4,4'-dimethyloxomatairesinol (2), (+)-(7S*,8R*,8'R*,9'S*)-9'-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6), and a triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (832) were isolated from the twigs of Pseudolarix kaempferi. Their structures were elucidated mainly by the analysis of their NMR and MS data. Pseudolarolide C acid (24) was isolated for the first time as a natural product. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and cytotoxic activity against K562, HT-29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines were assayed. Results indicated that the new compounds 3, 7, and some known compounds showed antimicrobial and cytotoxic activities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
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Extratos Vegetais
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Lignanas
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Pinaceae
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Glicosídeos
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Anti-Infecciosos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2011
Tipo de documento:
Article