Evaluation of insulin-like growth factor-1 in Indian growth hormone-deficient children on growth hormone therapy.
Endocr Res
; 36(3): 109-15, 2011.
Article
em En
| MEDLINE
| ID: mdl-21736493
ABSTRACT
OBJECTIVE:
To evaluate the impact of recombinant human growth hormone therapy (GHT) on serum insulin-like growth factor 1 (IGF-1) concentrations in Indian children with growth hormone deficiency.METHODS:
Data on anthropometry and serum IGF-1 concentrations were collected from 28 growth hormone-deficient prepubertal children (8.6 ± 2.9 years) on growth hormone therapy, 6 monthly over the period of 2 years.RESULTS:
Height z-scores showed a steady increase from baseline to 24 months. However, IGF-1 z-scores showed a plateau after the first 6 months and then a small dip followed by a rise. The pattern of increase of IGF-1 z-scores was dissimilar to that of the height z-scores.CONCLUSION:
The change in serum IGF-1 z-scores in response to GHT in Indian children may not be a good indicator for monitoring growth hormone responsiveness.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Hormônio do Crescimento Humano
/
Transtornos do Crescimento
Tipo de estudo:
Evaluation_studies
Limite:
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Endocr Res
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Índia