Anti-estrogen therapy for hereditary hemorrhagic telangiectasia - a long-term clinical trial.
Rhinology
; 49(2): 214-6, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21743879
ABSTRACT
STATEMENT OF PROBLEM:
Hereditary hemorrhagic telangiectasia (HHT) is associated with recurrent epistaxis in 90% of the cases. Good response to hormone treatment has been documented, although its use remains controversial. The aim of this study was to examine the efficacy of an anti-estrogenic agent, tamoxifen, in the treatment of HHT-associated epistaxis. METHOD OF STUDY Out of 46 patients with diagnosis of epistaxis due to HHT who started treatment with tamoxifen 20 mg/d, 38 patients completed a mean of 23.4 months of treatment. All patients filled out a self-assessment questionnaire of rhinologic Quality of Life and epistaxis grading scale. MAINRESULTS:
The bleeding score and the Quality of Life score improved. Hemoglobin concentration also improved. None of the patients needed blood transfusions during the treatment period. Only one patient had minor side effects of the drug. PRINCIPALCONCLUSIONS:
Tamoxifen appears to be an effective agent for the treatment of epistaxis due to HHT.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Telangiectasia Hemorrágica Hereditária
/
Epistaxe
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Rhinology
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Israel