Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.
J Cereb Blood Flow Metab
; 31(12): 2334-42, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21750562
ABSTRACT
The 5-hydroxytryptamine type 2a (5-HT(2A)) selective radiotracer [(18)F]altanserin has been subjected to a quantitative micro-positron emission tomography study in Lister Hooded rats. Metabolite-corrected plasma input modeling was compared with reference tissue modeling using the cerebellum as reference tissue. [(18)F]altanserin showed sufficient brain uptake in a distribution pattern consistent with the known distribution of 5-HT(2A) receptors. Full binding saturation and displacement was documented, and no significant uptake of radioactive metabolites was detected in the brain. Blood input as well as reference tissue models were equally appropriate to describe the radiotracer kinetics. [(18)F]altanserin is suitable for quantification of 5-HT(2A) receptor availability in rats.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ketanserina
/
Encéfalo
Limite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido