Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation.
Bioorg Med Chem Lett
; 21(16): 4750-2, 2011 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-21757350
ABSTRACT
The synthesis of two C-1 analogues of pancratistatin has been accomplished in 17 steps from bromobenzene. The key steps involved the enzymatic dihydroxylation, regioselective opening of epoxyaziridine 9 with the alane derived from 8, a solid-state silica-gel-catalyzed intramolecular opening of aziridine to produce phenanthrene 13 whose oxidative cleavage and recyclization provided the full skeleton of the Amaryllidaceae constituents. The new analogues 5 and 6 exhibited promising activity in several human cancer cell lines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Amaryllidaceae
/
Isoquinolinas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2011
Tipo de documento:
Article