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[The study on frequency distribution of regulatory T cells and its functional markers in peripheral blood of chronic hepatitis B].
Li, Chen; Xing, Shao-jun; Duan, Xue-zhang; Wan, Mo-bin; Wang, Hui-fen.
Afiliação
  • Li C; The Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Article em Zh | MEDLINE | ID: mdl-21789850
OBJECTIVE: To explore the role of treg cells and its functional markers in pathogenesis of chronic hepatitis B, and the correlation with disease progression. METHODS: 20 cases of healthy control people,53 cases of chronic hepatitis B patients and 24 cases of liver cirrhosis patients were enrolled into the groups. Detecting the frequencies of CD4+ CD25+ Fox3+ cells, CD4+ CD25+ CD127(low) cells, CD39+ treg cells and CTLA-4+ treg cells in treg cells by flow cytometry. Clinical parameters were investigated in the same time. RESULTS: The frequencies of treg cells, CD4+ CD25+ CD127(low) cells and CD39+ treg cells were significant different among healthy control group, CHB group and LC group (P < 0.01). The frequencies of treg cells, CD4+ CD25+ CD127(low) cells and CD39+ treg cells were significantly different in moderate-severe CHB group compared with mild CHB group (P < 0.05, P < 0.05, P < 0.01). In CHB group the frequencies of CD4+ CD25+ Foxp3+ cells were positively correlated with ALT (r = 0. 289, P < 0.05) and AST (r = 0.302, P < 0.05), the frequencies of CD4+ CD25+ Foxp3+ cells had a significant positive correlation with the frequencies of CD4+ CD25+ CD127(low) cells (r = 0.478, P < 0.01). CONCLUSION: The frequencies of treg cells and its functional markers probably had a dynamic tendency in the process of chronic hepatitis B and were closely related with the change of liver function parameters. CD39+ treg cells may be a group of functional treg cells, which indicated that CD39 be a sensitive marker to react treg cells function. In some sense, CD4+ CD25+ CD127(low) cells frequency could represent treg cell frequency.
Assuntos
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Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Hepatite B Crônica Limite: Adult / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi Assunto da revista: VIROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: China
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Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Hepatite B Crônica Limite: Adult / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi Assunto da revista: VIROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: China