A new subtype of Thottapalayam virus carried by the Asian house shrew (Suncus murinus) in China.
Infect Genet Evol
; 11(8): 1862-7, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21801855
ABSTRACT
Recently, many novel hantavirus species carried by insectivore had been found. In order to know whether the insectivore-associated hantaviruses exist in China, Asian house shrew (Suncus murinus) were analyzed for the presence of hantaviruses. 362 Asian house shrews were captured in Wenzhou of Zhejiang province. Hantavirus-specific RNA was detected by RT-PCR in lung tissue samples of six shrews. The complete hantavirus S and M segment sequences and also partial L segment sequences were successfully recovered. Pairwise comparison of the nucleotide and deduced amino acid sequences showed that the newly discovered virus strains are most closely related to Thottapalayam virus (TPMV) isolated from S. murinus in India, with 82.5-84.7% sequence identity at the nucleotide level and 95.0-98.2% at the amino acid level. Corresponding sequences of Imjin virus (MJNV) were more distant and other rodent- and insectivore-associated hantaviruses appeared even less related. Phylogenetic analysis revealed that the new variants formed a distinct lineage within TPMV.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Musaranhos
/
Orthohantavírus
/
Infecções por Hantavirus
Limite:
Animals
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Infect Genet Evol
Assunto da revista:
BIOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
GENETICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China