Cancer stem cells in the human mammary gland and regulation of their differentiation by estrogen.
Future Oncol
; 7(8): 995-1006, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21823894
ABSTRACT
The identification and characterization of normal and breast cancer stem cells have provided a new vision of breast tumorigenesis. Cancer stem cells may be responsible for breast tumor initiation, progression and development of resistance to therapy. Most breast cancers express the estrogen receptor, and several studies have linked long-term estrogen exposure to enhanced breast cancer risk; however, estrogen receptor-positive tumors usually present a better prognosis than estrogen receptor-negative ones. The finding that estrogen reduces the pool of human breast stem cells may explain the more differentiated phenotype observed in estrogen receptor-positive tumors. In this article, our current understanding of the complex role of estrogen in human breast stem cells is discussed in the context of breast malignancy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Diferenciação Celular
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Glândulas Mamárias Humanas
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Estrogênios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Espanha